2023 

Intestinal Knockout of Peroxisome Proliferator-activated Receptor-alpha Affects Structural Adaptation but not Liver Injury Following Massive Enterectomy 

February 17, 2023 

Phelps HM, Swanson KA, Steinberger AE, Guo J, King AC, Siddappa CM, Davidson NO, Rubin DC, Warner BW. Intestinal Knockout of Peroxisome Proliferator-activated Receptor-alpha Affects Structural Adaptation but not Liver Injury Following Massive Enterectomy. J Pediatr Surg. 2023 Feb 17:S0022-3468(23)00135-5. doi: 10.1016/j.jpedsurg.2023.02.016. Epub ahead of print. PMID: 36922278.  

Disruption of Enterohepatic Circulation of Bile Acids Ameliorates Small Bowel Resection Associated Hepatic Injury 

February 21, 2023 

Tecos ME, Steinberger AE, Guo J, Rubin DC, Davidson NO, Warner BW. Disruption of Enterohepatic Circulation of Bile Acids Ameliorates Small Bowel Resection Associated Hepatic Injury. J Pediatr Surg. 2023 Feb 21:S0022-3468(23)00152-5. doi: 10.1016/j.jpedsurg.2023.02.031. Epub ahead of print. PMID: 36914459. 

2022 

Fecal microbiome and bile acid metabolome in adult short bowel syndrome

January 1, 2022 

Boutte HJ Jr, Chen J, Wylie TN, Wylie KM, Xie Y, Geisman M, Prabu A, Gazit V, Tarr PI, Levin MS, Warner BW, Davidson NO, Rubin DC. Fecal microbiome and bile acid metabolome in adult short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2022 Jan 1;322(1):G154-G168. doi: 10.1152/ajpgi.00091.2021. Epub 2021 Nov 24. PMID: 34816756; PMCID: PMC8793869.  

SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling 

January 6, 2022 

Gu W, Wang H, Huang X, Kraiczy J, Singh PNP, Ng C, Dagdeviren S, Houghton S, Pellon-Cardenas O, Lan Y, Nie Y, Zhang J, Banerjee KK, Onufer EJ, Warner BW, Spence J, Scherl E, Rafii S, Lee RT, Verzi MP, Redmond D, Longman R, Helin K, Shivdasani RA, Zhou Q. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell. 2022 Jan 6;29(1):101-115.e10. doi: 10.1016/j.stem.2021.09.004. Epub 2021 Sep 27. PMID: 34582804; PMCID: PMC8741647.  

Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice 

July 7, 2022 

Onufer EJ, Czepielewski RS, Han YH, Courtney CM, Sutton S, Sescleifer A, Randolph GJ, Warner BW. Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice. Sci Rep. 2022 Jul 7;12(1):11527. doi: 10.1038/s41598-022-15848-6. PMID: 35798817; PMCID: PMC9262882. 

A novel maladaptive unfolded protein response as a mechanism for small bowel resection-induced liver injury 

September 1, 2022 

Steinberger AE, Tecos ME, Phelps HM, Rubin DC, Davidson NO, Guo J, Warner BW. A novel maladaptive unfolded protein response as a mechanism for small bowel resection-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2022 Sep 1;323(3):G165-G176. doi: 10.1152/ajpgi.00302.2021. Epub 2022 Jun 21. PMID: 35727920; PMCID: PMC9377788. 

Distal Small Bowel Resection Yields Enhanced Intestinal and Colonic Adaptation 

May 2022 

Tecos ME, Steinberger AE, Guo J, Warner BW. Distal Small Bowel Resection Yields Enhanced Intestinal and Colonic Adaptation. J Surg Res. 2022 May;273:100-109. doi: 10.1016/j.jss.2021.11.015. Epub 2022 Jan 13. PMID: 35033819. 

Being small for gestational age is not an independent risk factor for mortality in neonates with congenital diaphragmatic hernia: a multicenter study 

September 2022 

Zenilman A, Fan W, Hernan R, Wynn J, Abramov A, Farkouh-Karoleski C, Aspelund G, Krishnan US, Khlevner J, Azarow K, Crombleholme T, Cusick R, Chung D, Danko ME, Potoka D, Lim FY, McCulley DJ, Mychaliska GB, Schindel D, Soffer S, Wagner AJ, Warner BW, Chung WK, Duron VP. Being small for gestational age is not an independent risk factor for mortality in neonates with congenital diaphragmatic hernia: a multicenter study. J Perinatol. 2022 Sep;42(9):1183-1188. doi: 10.1038/s41372-022-01326-4. Epub 2022 Apr 21. PMID: 35449444. 

2021 

Risk factors for perioperative hypothermia and infectious outcomes in gastroschisis patients 

July 2021 

Bence CM, Landisch RM, Wu R, Szabo A, McElhinney K, Austin MT, Fraser JD, St Peter SD, Joshi S, Lillegard JB, Tay S, Warner BW, Kim AG, Perrone EE, Leys CM, Kohler JE, Wagner AJ. Risk factors for perioperative hypothermia and infectious outcomes in gastroschisis patients. J Pediatr Surg. 2021 Jul;56(7):1107-1112. doi: 10.1016/j.jpedsurg.2021.03.020. Epub 2021 Mar 26. PMID: 33865604. 

Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4 

February 2021 

Courtney CM, Onufer EJ, McDonald KG, Steinberger AE, Sescleifer AM, Seiler KM, Tecos ME, Newberry RD, Warner BW. Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4. J Surg Res. 2021 Feb;258:73-81. doi: 10.1016/j.jss.2020.08.049. Epub 2020 Sep 28. PMID: 33002664; PMCID: PMC7937530.  

Enterically derived high-density lipoprotein restrains liver injury through the portal vein 

July 23, 2021 

Han YH, Onufer EJ, Huang LH, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science. 2021 Jul 23;373(6553):eabe6729. doi: 10.1126/science.abe6729. PMID: 34437091; PMCID: PMC8478306. 

Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice 

May 1, 2021 

Onufer EJ, Han YH, Courtney C, Steinberger A, Tecos M, Sutton S, Sescleifer A, Ou J, Sanguinetti Czepielewski R, Randolph GJ, Warner BW. Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice. Am J Physiol Gastrointest Liver Physiol. 2021 May 1;320(5):G907-G918. doi: 10.1152/ajpgi.00284.2020. Epub 2021 Mar 17. PMID: 33729834; PMCID: PMC8202193. 

Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene 

October 7, 2021 

Qiao L, Xu L, Yu L, Wynn J, Hernan R, Zhou X, Farkouh-Karoleski C, Krishnan US, Khlevner J, De A, Zygmunt A, Crombleholme T, Lim FY, Needelman H, Cusick RA, Mychaliska GB, Warner BW, Wagner AJ, Danko ME, Chung D, Potoka D, Kosiński P, McCulley DJ, Elfiky M, Azarow K, Fialkowski E, Schindel D, Soffer SZ, Lyon JB, Zalieckas JM, Vardarajan BN, Aspelund G, Duron VP, High FA, Sun X, Donahoe PK, Shen Y, Chung WK. Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene. Am J Hum Genet. 2021 Oct 7;108(10):1964-1980. doi: 10.1016/j.ajhg.2021.08.011. Epub 2021 Sep 20. PMID: 34547244; PMCID: PMC8546037. 

Antibiotic-driven intestinal dysbiosis in pediatric short bowel syndrome is associated with persistently altered microbiome functions and gut-derived bloodstream infections 

January 2021 

Thänert R, Thänert A, Ou J, Bajinting A, Burnham CD, Engelstad HJ, Tecos ME, Ndao IM, Hall-Moore C, Rouggly-Nickless C, Carl MA, Rubin DC, Davidson NO, Tarr PI, Warner BB, Dantas G, Warner BW. Antibiotic-driven intestinal dysbiosis in pediatric short bowel syndrome is associated with persistently altered microbiome functions and gut-derived bloodstream infections. Gut Microbes. 2021 Jan-Dec;13(1):1940792. doi: 10.1080/19490976.2021.1940792. PMID: 34264786; PMCID: PMC8284144. 

2020 

Comparative outcomes of right versus left congenital diaphragmatic hernia: A multicenter analysis 

January 2020 

Abramov A, Fan W, Hernan R, Zenilman AL, Wynn J, Aspelund G, Khlevner J, Krishnan U, Lim FY, Mychaliska GB, Warner BW, Cusick R, Crombleholme T, Chung D, Danko ME, Wagner AJ, Azarow K, Schindel D, Potoka D, Soffer S, Fisher J, McCulley D, Farkouh-Karoleski C, Chung WK, Duron V. Comparative outcomes of right versus left congenital diaphragmatic hernia: A multicenter analysis. J Pediatr Surg. 2020 Jan;55(1):33-38. doi: 10.1016/j.jpedsurg.2019.09.046. Epub 2019 Oct 26. PMID: 31677822.  

Multicenter retrospective comparison of spontaneous intestinal perforation outcomes between primary peritoneal drain and primary laparotomy  

July 2020 

Ahle S, Badru F, Damle R, Osei H, Munoz-Abraham AS, Bajinting A, Barbian ME, Bhatia AM, Gingalewski C, Greenspon J, Hamilton N, Stitelman D, Strand M, Warner BW, Villalona GA. Multicenter retrospective comparison of spontaneous intestinal perforation outcomes between primary peritoneal drain and primary laparotomy. J Pediatr Surg. 2020 Jul;55(7):1270-1275. doi: 10.1016/j.jpedsurg.2019.07.007. Epub 2019 Jul 19. PMID: 31383579.  

Increased Adiposity and Reduced Lean Body Mass in Patients with Short Bowel Syndrome 

November 2020 

Chiplunker AJ, Chen L, Levin MS, Warner BW, Davidson NO, Rubin DC. Increased Adiposity and Reduced Lean Body Mass in Patients with Short Bowel Syndrome. Dig Dis Sci. 2020 Nov;65(11):3271-3279. doi: 10.1007/s10620-019-06032-4. Epub 2020 Jan 7. PMID: 31907775; PMCID: PMC7924810.  

Alterations in pancreatic islet cell function in response to small bowel resection 

July 1, 2020 

Courtney CM, Shyr ZA, Yan Z, Onufer EJ, Steinberger AE, Tecos ME, Barron LK, Guo J, Remedi MS, Warner BW. Alterations in pancreatic islet cell function in response to small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G36-G42. doi: 10.1152/ajpgi.00282.2019. Epub 2020 May 28. PMID: 32463335; PMCID: PMC7468758.  

Changing the Paradigm for Management of Pediatric Primary Spontaneous Pneumothorax: A Simple Aspiration Test Predicts Need for Operation 

January 2020  

Leys CM, Hirschl RB, Kohler JE, Cherney-Stafford L, Marka N, Fallat ME, Gadepalli SK, Fraser JD, Grabowski J, Burns RC, Downard CD, Foley DS, Halleran DR, Helmrath MA, Kabre R, Knezevich MS, Lal DR, Landman MP, Lawrence AE, Mak GZ, Minneci PC, Musili N, Rymeski B, Saito JM, Sato TT, St Peter SD, Warner BW, Ostlie DJ; Midwest Pediatric Surgery Consortium MWPSC. Changing the Paradigm for Management of Pediatric Primary Spontaneous Pneumothorax: A Simple Aspiration Test Predicts Need for Operation. J Pediatr Surg. 2020 Jan;55(1):169-175. doi: 10.1016/j.jpedsurg.2019.09.043. Epub 2019 Oct 24. PMID: 31706614.  

Extracorporeal Membrane Oxygenation for Pediatric Patients With Coronavirus Disease 2019-Related Illness 

October 2020 

MacGregor RM, Antiel RM, Najaf T, Said AS, Warner BW, Raval MV, Shakhsheer B. Extracorporeal Membrane Oxygenation for Pediatric Patients With Coronavirus Disease 2019-Related Illness. Pediatr Crit Care Med. 2020 Oct;21(10):893-897. doi: 10.1097/PCC.0000000000002432. PMID: 32427689; PMCID: PMC7523473.  

EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis 

September 15, 2020 

Onufer EJ, Aladegbami B, Imai T, Seiler K, Bajinting A, Courtney C, Sutton S, Bustos A, Yao J, Yeh CH, Sescleifer A, Wang LV, Guo J, Warner BW. EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis. PLoS One. 2020 Sep 15;15(9):e0236964. doi: 10.1371/journal.pone.0236964. PMID: 32931498; PMCID: PMC7491746.  

Effects of high-fat diet on liver injury after small bowel resection 

June 2020 

Onufer EJ, Han YH, Czepielewski RS, Courtney CM, Sutton S, Randolph GJ, Warner BW. Effects of high-fat diet on liver injury after small bowel resection. J Pediatr Surg. 2020 Jun;55(6):1099-1106. doi: 10.1016/j.jpedsurg.2020.02.037. Epub 2020 Feb 28. PMID: 32164985; PMCID: PMC7299751.  

Nutrition in Necrotizing Enterocolitis and Following Intestinal Resection 

February 18, 2020 

Ou J, Courtney CM, Steinberger AE, Tecos ME, Warner BW. Nutrition in Necrotizing Enterocolitis and Following Intestinal Resection. Nutrients. 2020 Feb 18;12(2):520. doi: 10.3390/nu12020520. PMID: 32085587; PMCID: PMC7071274. 

Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes 

December 2020 

Qiao L, Wynn J, Yu L, Hernan R, Zhou X, Duron V, Aspelund G, Farkouh-Karoleski C, Zygumunt A, Krishnan US, Nees S, Khlevner J, Lim FY, Crombleholme T, Cusick R, Azarow K, Danko ME, Chung D, Warner BW, Mychaliska GB, Potoka D, Wagner AJ, Soffer S, Schindel D, McCulley DJ, Shen Y, Chung WK. Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes. Genet Med. 2020 Dec;22(12):2020-2028. doi: 10.1038/s41436-020-0908-0. Epub 2020 Jul 28. PMID: 32719394; PMCID: PMC7710626.  

Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model 

March 2, 2020 

Seiler KM, Bajinting A, Alvarado DM, Traore MA, Binkley MM, Goo WH, Lanik WE, Ou J, Ismail U, Iticovici M, King CR, VanDussen KL, Swietlicki EA, Gazit V, Guo J, Luke CJ, Stappenbeck T, Ciorba MA, George SC, Meacham JM, Rubin DC, Good M, Warner BW. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Sci Rep. 2020 Mar 2;10(1):3842. doi: 10.1038/s41598-020-60672-5. PMID: 32123209; PMCID: PMC7051952.  

Adaptation of extracellular matrix to massive small bowel resection in mice 

June 2020 

Seiler KM, Goo WH, Zhang Q, Courtney C, Bajinting A, Guo J, Warner BW. Adaptation of extracellular matrix to massive small bowel resection in mice. J Pediatr Surg. 2020 Jun;55(6):1107-1112. doi: 10.1016/j.jpedsurg.2020.02.038. Epub 2020 Feb 27. PMID: 32164986; PMCID: PMC7299777. 

2019 

Maintenance of piercing tracts in the perioperative period 

May 2019 

Drobish JK, Warner BW. Maintenance of piercing tracts in the perioperative period. J Clin Anesth. 2019 May;54:85-86. doi: 10.1016/j.jclinane.2018.10.021. Epub 2018 Nov 6. PMID: 30412816.  

Lymphatic network remodeling after small bowel resection 

June 2019 

Onufer EJ, Czepielewski R, Seiler KM, Erlich E, Courtney CM, Bustos A, Randolph GJ, Warner BW. Lymphatic network remodeling after small bowel resection. J Pediatr Surg. 2019 Jun;54(6):1239-1244. doi: 10.1016/j.jpedsurg.2019.02.026. Epub 2019 Feb 28. PMID: 30879758; PMCID: PMC6545263. 

Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in Mice 

June 2019 

Seiler KM, Waye SE, Kong W, Kamimoto K, Bajinting A, Goo WH, Onufer EJ, Courtney C, Guo J, Warner BW, Morris SA. Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in Mice. Cell Mol Gastroenterol Hepatol. 2019;8(3):407-426. doi: 10.1016/j.jcmgh.2019.06.001. Epub 2019 Jun 10. PMID: 31195149; PMCID: PMC6718927. 

Short Bowel Syndrome 

December 2019 

Shakhsheer BA, Warner BW. Short Bowel Syndrome. Curr Treat Options Pediatr. 2019 Dec;5(4):494-505. doi: 10.1007/s40746-019-00179-y. Epub 2019 Oct 11. PMID: 33312846; PMCID: PMC7728382. 

Impaired Chylomicron Assembly Modifies Hepatic Metabolism Through Bile Acid-Dependent and Transmissible Microbial Adaptations 

October 2019 

Xie Y, Matsumoto H, Kennedy S, Newberry EP, Moritz W, DeBosch BJ, Moley KH, Rubin DC, Warner BW, Kau AL, Tarr PI, Wylie TN, Wylie KM, Davidson NO. Impaired Chylomicron Assembly Modifies Hepatic Metabolism Through Bile Acid-Dependent and Transmissible Microbial Adaptations. Hepatology. 2019 Oct;70(4):1168-1184. doi: 10.1002/hep.30669. Epub 2019 May 23. PMID: 31004524; PMCID: PMC6783349. 

2018
Intestinal resection-associated metabolic syndrome 

June 2018 

Barron L, Courtney C, Bao J, Onufer E, Panni RZ, Aladegbami B, Warner BW. Intestinal resection-associated metabolic syndrome. J Pediatr Surg. 2018 Jun;53(6):1142-1147. doi: 10.1016/j.jpedsurg.2018.02.077. Epub 2018 Mar 7. PMID: 29588076; PMCID: PMC5994370.

An anatomic approach to understanding mechanisms of intestinal adaptation 

August 2018 

Courtney CM, Onufer EJ, Seiler KM, Warner BW. An anatomic approach to understanding mechanisms of intestinal adaptation. Semin Pediatr Surg. 2018 Aug;27(4):229-236. doi: 10.1053/j.sempedsurg.2018.07.002. Epub 2018 Jul 29. PMID: 30342597. 

Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth 

October 2018 

Engelstad HJ, Barron L, Moen J, Wylie TN, Wylie K, Rubin DC, Davidson N, Cade WT, Warner BB, Warner BW. Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth. J Am Coll Surg. 2018 Oct;227(4):439-449. doi: 10.1016/j.jamcollsurg.2018.07.657. Epub 2018 Aug 2. PMID: 30077861; PMCID: PMC6162148. 

Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis 

June 2018 

Isani M, Illingworth L, Herman E, Schmidt M, Barron L, Bowling J, Elizee M, Bai I, Gayer C, Grishin A, Erwin CR, Ford HR, Warner BW. Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Jun;53(6):1203-1207. doi: 10.1016/j.jpedsurg.2018.02.084. Epub 2018 Mar 8. PMID: 29636182. 

Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice 

November 10, 2018 

Onufer EJ, Tay S, Barron LK, Courtney CM, Warner BW, Guo J. Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1174-1179. doi: 10.1016/j.bbrc.2018.10.040. Epub 2018 Oct 12. PMID: 30318117; PMCID: PMC6248877. 

2017
Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine 

July 17, 2017 

Aladegbami B, Barron L, Bao J, Colasanti J, Erwin CR, Warner BW, Guo J. Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine. Sci Rep. 2017 Jul 17;7(1):5580. doi: 10.1038/s41598-017-06070-w. PMID: 28717211; PMCID: PMC5514129. 

Toll-like receptor 4 is critical for the development of resection-associated hepatic steatosis 

June 2017 

Barron LK, Bao JW, Aladegbami BG, Colasanti JJ, Guo J, Erwin CR, Warner BW. Toll-like receptor 4 is critical for the development of resection-associated hepatic steatosis. J Pediatr Surg. 2017 Jun;52(6):1014-1019. doi: 10.1016/j.jpedsurg.2017.03.026. Epub 2017 Mar 16. PMID: 28351520; PMCID: PMC5466889. 

Epithelial IGF1R is dispensable for IGF2 mediated enhanced intestinal adaptation in retinoblastoma-deficient mice 

June 2017 

Sun RC, Choi PM, Diaz-Miron JL, Sommovilla J, Guo J, Erwin CR, Warner BW. Epithelial IGF1R is dispensable for IGF2 mediated enhanced intestinal adaptation in retinoblastoma-deficient mice. J Pediatr Surg. 2017 Jun;52(6):1026-1030. doi: 10.1016/j.jpedsurg.2017.03.030. Epub 2017 Mar 18. PMID: 28343662; PMCID: PMC5466888. 

2016
Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection 

December 2016 

Barron L, Sun RC, Aladegbami B, Erwin CR, Warner BW, Guo J. Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection. Cell Mol Gastroenterol Hepatol. 2016 Dec 10;3(2):231-244. doi: 10.1016/j.jcmgh.2016.10.006. PMID: 28275690; PMCID: PMC5331783. 

Liver steatosis induced by small bowel resection is prevented by oral vancomycin 

December 2016 

Barron LK, Gayer CP, Roberts A, Golden JM, Aladegbami BG, Guo J, Erwin CR, Warner BW. Liver steatosis induced by small bowel resection is prevented by oral vancomycin. Surgery. 2016 Dec;160(6):1485-1495. doi: 10.1016/j.surg.2016.07.018. Epub 2016 Aug 31. PMID: 27592213; PMCID: PMC5409838. 

Transgenic Soybean Production of Bioactive Human Epidermal Growth Factor (EGF) 

June 17 2016 

He Y, Schmidt MA, Erwin C, Guo J, Sun R, Pendarvis K, Warner BW, Herman EM. Transgenic Soybean Production of Bioactive Human Epidermal Growth Factor (EGF). PLoS One. 2016 Jun 17;11(6):e0157034. doi: 10.1371/journal.pone.0157034. PMID: 27314851; PMCID: PMC4912142. 

2015
The effect of impaired angiogenesis on intestinal function following massive small bowel resection 

June 2015 

Diaz-Miron J, Sun R, Choi P, Sommovilla J, Guo J, Erwin CR, Mei J, Scott Worthen G, Warner BW. The effect of impaired angiogenesis on intestinal function following massive small bowel resection. J Pediatr Surg. 2015 Jun;50(6):948-53. doi: 10.1016/j.jpedsurg.2015.03.014. Epub 2015 Mar 14. PMID: 25818317; PMCID: PMC4439276. 

High-protein diet improves postoperative weight gain after massive small-bowel resection 

March 2015 

Sun RC, Choi PM, Diaz-Miron J, Sommovilla J, Guo J, Erwin CR, Warner BW. High-protein diet improves postoperative weight gain after massive small-bowel resection. J Gastrointest Surg. 2015 Mar;19(3):451-7. doi: 10.1007/s11605-014-2715-x. Epub 2014 Dec 18. PMID: 25519080; PMCID: PMC4965231. 

Both epidermal growth factor and insulin-like growth factor receptors are dispensable for structural intestinal adaptation 

June 2015 

Sun RC, Diaz-Miron JL, Choi PM, Sommovilla J, Guo J, Erwin CR, Warner BW. Both epidermal growth factor and insulin-like growth factor receptors are dispensable for structural intestinal adaptation. J Pediatr Surg. 2015 Jun;50(6):943-7. doi: 10.1016/j.jpedsurg.2015.03.015. Epub 2015 Mar 14. PMID: 25818318; PMCID: PMC4439349. 

2014
Disruption of retinoblastoma protein expression in the intestinal epithelium impairs lipid absorption 

May 15, 2014 

Choi PM, Guo J, Erwin CR, Wandu WS, Leinicke JA, Xie Y, Davidson NO, Warner BW. Disruption of retinoblastoma protein expression in the intestinal epithelium impairs lipid absorption. Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G909-15. doi: 10.1152/ajpgi.00067.2014. Epub 2014 Apr 17. PMID: 24742992; PMCID: PMC4024723. 

High-fat diet enhances villus growth during the adaptation response to massive proximal small bowel resection 

February 2014 

Choi PM, Sun RC, Guo J, Erwin CR, Warner BW. High-fat diet enhances villus growth during the adaptation response to massive proximal small bowel resection. J Gastrointest Surg. 2014 Feb;18(2):286-94; discussion 294. doi: 10.1007/s11605-013-2338-7. Epub 2013 Sep 4. PMID: 24002772; PMCID: PMC4409787. 

IGF-2 is necessary for retinoblastoma-mediated enhanced adaptation after small-bowel resection 

November 2014 

Choi PM, Sun RC, Sommovilla J, Diaz-Miron J, Guo J, Erwin CR, Warner BW. IGF-2 is necessary for retinoblastoma-mediated enhanced adaptation after small-bowel resection. J Gastrointest Surg. 2014 Nov;18(11):1887-93. doi: 10.1007/s11605-014-2586-1. Epub 2014 Jul 8. PMID: 25002022; PMCID: PMC4201888. 

The role of enteral fat as a modulator of body composition after small bowel resection 

August 2014 

Choi PM, Sun RC, Sommovilla J, Diaz-Miron J, Khil J, Erwin CR, Guo J, Warner BW. The role of enteral fat as a modulator of body composition after small bowel resection. Surgery. 2014 Aug;156(2):412-8. doi: 10.1016/j.surg.2014.03.013. Epub 2014 Mar 14. PMID: 24713095; PMCID: PMC4099283. 

CXCL5 is required for angiogenesis, but not structural adaptation after small bowel resection 

June 2014 

Rowland KJ, Diaz-Miron J, Guo J, Erwin CR, Mei J, Worthen GS, Warner BW. CXCL5 is required for angiogenesis, but not structural adaptation after small bowel resection. J Pediatr Surg. 2014 Jun;49(6):976-80; discussion 980. doi: 10.1016/j.jpedsurg.2014.01.034. Epub 2014 Feb 3. PMID: 24888846; PMCID: PMC4044536. 

Insulin-like growth factor 2 and its enterocyte receptor are not required for adaptation in response to massive small bowel resection 

Sun RC, Choi PM, Guo J, Erwin CR, Warner BW. Insulin-like growth factor 2 and its enterocyte receptor are not required for adaptation in response to massive small bowel resection. J Pediatr Surg. 2014 Jun;49(6):966-70; discussion 970. doi: 10.1016/j.jpedsurg.2014.01.035. Epub 2014 Jan 31. PMID: 24888844; PMCID: PMC4044537. 

2013
IGF-2 mediates intestinal mucosal hyperplasia in retinoblastoma protein (Rb)-deficient mice 

June 2013 

Choi P, Guo J, Erwin CR, Warner BW. IGF-2 mediates intestinal mucosal hyperplasia in retinoblastoma protein (Rb)-deficient mice. J Pediatr Surg. 2013 Jun;48(6):1340-7. doi: 10.1016/j.jpedsurg.2013.03.042. PMID: 23845628; PMCID: PMC3885982. 

Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection 

June 2013 

Rowland KJ, Yao J, Wang L, Erwin CR, Maslov KI, Wang LV, Warner BW. Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection. J Pediatr Surg. 2013 Jun;48(6):1330-9. doi: 10.1016/j.jpedsurg.2013.03.031. PMID: 23845627; PMCID: PMC3755458. 

2012
Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection 

May 15, 2012 

Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW. Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1143-50. doi: 10.1152/ajpgi.00296.2011. Epub 2012 Mar 15. PMID: 22421622; PMCID: PMC3362098. 

Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection 

September 2012 

Rowland KJ, McMellen ME, Wakeman D, Wandu WS, Erwin CR, Warner BW. Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection. J Pediatr Surg. 2012 Sep;47(9):1748-53. doi: 10.1016/j.jpedsurg.2012.03.089. PMID: 22974617; PMCID: PMC3443391. 

Immediate alterations in intestinal oxygen saturation and blood flow after massive small bowel resection as measured by photoacoustic microscopy 

June 2012 

Rowland KJ, Yao J, Wang L, Erwin CR, Maslov KI, Wang LV, Warner BW. Immediate alterations in intestinal oxygen saturation and blood flow after massive small bowel resection as measured by photoacoustic microscopy. J Pediatr Surg. 2012 Jun;47(6):1143-9. doi: 10.1016/j.jpedsurg.2012.03.020. PMID: 22703784; PMCID: PMC3377986. 

p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection 

May 1, 2012 

Wakeman D, Guo J, Santos JA, Wandu WS, Schneider JE, McMellen ME, Leinicke JA, Erwin CR, Warner BW. p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G997-1005. doi: 10.1152/ajpgi.00485.2011. Epub 2012 Mar 1. PMID: 22383494; PMCID: PMC3362074. 

Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis 

August 2012 

Wakeman D, Schneider JE, Liu J, Wandu WS, Erwin CR, Guo J, Stappenbeck TS, Warner BW. Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis. Surgery. 2012 Aug;152(2):286-93. doi: 10.1016/j.surg.2012.05.009. PMID: 22828150; PMCID: PMC3408636. 

2011
Bacterial DNA content in the intestinal wall from infants with necrotizing enterocolitis 

June 2011 

Bucher BT, McDuffie LA, Shaikh N, Tarr PI, Warner BB, Hamvas A, White FV, Erwin CR, Warner BW. Bacterial DNA content in the intestinal wall from infants with necrotizing enterocolitis. J Pediatr Surg. 2011 Jun;46(6):1029-33. doi: 10.1016/j.jpedsurg.2011.03.026. PMID: 21683193; PMCID: PMC3118995. 

Intestinal adaptation after small bowel resection in human infants 

June 2011 

McDuffie LA, Bucher BT, Erwin CR, Wakeman D, White FV, Warner BW. Intestinal adaptation after small bowel resection in human infants. J Pediatr Surg. 2011 Jun;46(6):1045-51. doi: 10.1016/j.jpedsurg.2011.03.027. PMID: 21683196; PMCID: PMC3121576. 

2010
Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection 

August 2010 

McMellen ME, Wakeman D, Erwin CR, Guo J, Warner BW. Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery. 2010 Aug;148(2):364-70. doi: 10.1016/j.surg.2010.03.020. Epub 2010 May 14. PMID: 20471049; PMCID: PMC2917230. 

Extent of small bowel resection does not influence the magnitude of intestinal adaptation in the mouse 

June 2010 

Wakeman D, Longshore SW, McMellen ME, Santos JA, Guo J, Erwin CR, Warner BW. Extent of small bowel resection does not influence the magnitude of intestinal adaptation in the mouse. J Pediatr Surg. 2010 Jun;45(6):1274-9. doi: 10.1016/j.jpedsurg.2010.02.101. PMID: 20620331; PMCID: PMC3112353. 

2009
Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine 

January 2, 2009 

Guo J, Longshore S, Nair R, Warner BW. Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine. J Biol Chem. 2009 Jan 2;284(1):134-140. doi: 10.1074/jbc.M806133200. Epub 2008 Nov 3. PMID: 18981186; PMCID: PMC2610504. 

p21(waf1/cip1) deficiency does not perturb the intestinal crypt stem cell population after massive small bowel resection 

June 2009 

Longshore SW, Nair R, Perrone EE, Erwin CR, Guo J, Warner BW. p21(waf1/cip1) deficiency does not perturb the intestinal crypt stem cell population after massive small bowel resection. J Pediatr Surg. 2009 Jun;44(6):1065-71; discussion 1071. doi: 10.1016/j.jpedsurg.2009.02.034. PMID: 19524718; PMCID: PMC2697119. 

Intestinal resection induces angiogenesis within adapting intestinal villi 

June 2009 

Martin CA, Perrone EE, Longshore SW, Toste P, Bitter K, Nair R, Guo J, Erwin CR, Warner BW. Intestinal resection induces angiogenesis within adapting intestinal villi. J Pediatr Surg. 2009 Jun;44(6):1077-82; discussion 1083. doi: 10.1016/j.jpedsurg.2009.02.036. PMID: 19524720; PMCID: PMC2697129. 

2008
Resection-induced intestinal adaptation and the role of enteric smooth muscle 

June 2008 

Martin CA, Bernabe KQ, Taylor JA, Nair R, Paul RJ, Guo J, Erwin CR, Warner BW. Resection-induced intestinal adaptation and the role of enteric smooth muscle. J Pediatr Surg. 2008 Jun;43(6):1011-7. doi: 10.1016/j.jpedsurg.2008.02.015. PMID: 18558175. 

Body composition and metabolic changes associated with massive intestinal resection in mice 

January 2008 

Tantemsapya N, Meinzner-Derr J, Erwin CR, Warner BW. Body composition and metabolic changes associated with massive intestinal resection in mice. J Pediatr Surg. 2008 Jan;43(1):14-9. doi: 10.1016/j.jpedsurg.2007.09.010. PMID: 18206448. 

Lessons learned: optimization of a murine small bowel resection model 

June 2008 

Taylor JA, Martin CA, Nair R, Guo J, Erwin CR, Warner BW. Lessons learned: optimization of a murine small bowel resection model. J Pediatr Surg. 2008 Jun;43(6):1018-24. doi: 10.1016/j.jpedsurg.2008.02.025. PMID: 18558176; PMCID: PMC2481288.